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血浆皮质醇水平与老年抑郁症状的关系——基于 如皋衰老队列
唐顾原姚舜王笑峰
()
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目的 探究血浆皮质醇水平与老年群体抑郁症状的关系。方法 采用如皋衰老队列 (RuLAS)2017 年的调查数据,共纳入 1 744 例 70~89 岁老年人,采用老年抑郁症状量表(GDS-15)对被试 者的抑郁症状进行评分(≥5分为抑郁),晨间采血用以测量被试者的血糖和血浆皮质醇水平,采用面对面的 方式完成多维度的健康评估调查问卷,并由受训练医师完成体格检查。结果 如皋老年人群抑郁症状的 患病率为16.5%(288/1 744);肥胖人群中(BMI>28.0 kg/m2 ),抑郁老人的皮质醇水平[(13.60±3.99)μmol/dl] 显著高于非抑郁组[(11.51±4.06)μmol/dl],差异有统计学意义(t=2.939,P< 0.01);在肥胖组中,调整 了人口统计学、健康行为方式等后,血浆皮质醇水平的升高与老年抑郁症状风险的增加相关(OR=1.22, 95%CI=1.08~1.37,P< 0.05)。结论 在如皋的肥胖老年人群中,血浆皮质醇水平的升高与抑郁症状出 现的风险相关。
关键词:  老年人  抑郁  皮质醇  肥胖症
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Association between plasma cortisol level and elderly depressive symptoms: based on the Rugao longevity and ageing study
()
Abstract:
Objective To explore the relationship between plasma cortisol level and elderly depressive symptoms. Methods Data was collected from the Rugao Longevity and Ageing Study (RuLAS) in 2017, including 1 744 older Chinese (aged from 70 to 89). The Geriatric Depression Scale (GDS-15) was used to examine the depressive symptoms in participants (≥ 5 points as depressive); morning blood collection was used to measure the glucose and plasma cortisol level; face to face multidimensional health assessment questionnaire was also administrated. Physical exams were performed by trained physicians. Results The prevalence of depression symptoms in Rugao elderly population was 16.5%(288/1 744); in obese elderly people (BMI > 28.0 kg/m2 ), the cortisol level [(13.60±3.99) μmol/dl] of the depressed elderly was significantly higher than that of the non-depressed group [(11.51±4.06) μmol/dl], and the difference was statistically significant (t=2.939, P< 0.01); In the obese group, after adjusting demographics, healthy behaviors and other factors, the increase in plasma cortisol levels was associated with an increased risk of depressive symptoms in the elderly (OR=1.22, 95%CI=1.08-1.37,P< 0.05). Conclusions In obese elderly people in Rugao, elevated plasma cortisol levels are associated with the risk of depressive symptoms.
Key words:  Aged  Depression  Cortisol  Obesity

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