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抑郁症性别差异相关原因的研究进展
汪晓王刚周晶晶
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抑郁症是一种常见的情感障碍性的疾病,是全球疾病负担的一个主要因素。抑郁症的发 病率存在一定的性别差异,女性更易患抑郁症。抑郁症性别差异的产生可能会导致治疗及干预的个体 化差异,但目前这种差异产生的机制尚未完全明确,可能为多因素共同作用所致。现将从性激素、遗传、 免疫和社会心理因素的角度对抑郁症的性别差异的产生进行分析,以进一步了解抑郁症性别差异的发 病机制和神经病理学基础。
关键词:  抑郁症  性别差异  相关原因  综述
基金项目:国家重点研发计划(2016YFC1307200);北京市医院管理局“登峰”人才培养计划 (DFL20151801);北京市属医院科研培育计划(PX2018064)
Research progress on the relevant reasons of gender difference in depression
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Abstract:
Depression is a common affective disorder and a major factor in the global burden of disease. There is a gender difference in the incidence of depression, and women are more likely to suffer from depression. Gender difference in depression may lead to individualized differences in treatment and intervention, but the mechanism of such differences has not yet been fully defined, and it may be caused by multiple factors. This paper will analyze the gender difference of depression from the perspectives of sex hormone, heredity, immunity and psychosocial factors, so as to further understand the pathogenesis and neuropathological basis of the gender difference of depression.

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