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电生理技术在阿尔茨海默病早期应用的研究进展
俞越姚群叶星石静萍
()
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脑磁图(MEG)及脑电图(EEG)均是非侵入性的神经电生理检查技术,能够在早期发现突 触功能障碍并跟踪疾病进展。尽管它们有特殊的神经生理学意义,但目前并未被列为阿尔茨海默病(AD) 疾病谱临床诊断的一部分。现总结 MEG/EEG 在解释 AD 疾病谱病理生理机制中的作用,综述二者对 AD 临床前期及痴呆前期的诊断价值以及对预测 AD 早期患者疾病进展风险的作用。
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Research progress on electrophysiological study of early stage of Alzheimer disease
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Abstract:
Magnetoencephalography (MEG) and Electroencephalogram (EEG) (MEG/EEG) are both non-invasive neuroelectrophysiological technologies, which can detect synaptic dysfunction in the early stage of disease and track the disease progression. Although they imply special neurophysiological significance, they have not yet listed as biomarks for diagnosis of Alzheimer disease (AD) continuum so far. This paper discussed the role of MEG/EEG in the pathophysiological mechanism of the AD-continuum. This paper also reviewed the diagnostic value of MEG/EEG in pre-clinical and pre-dementia stage of AD and their effects in predicting disease progression of early AD patients.

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